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Aurora TX

Gain more insights into your samples with automated secondary structure characterization of proteins and RNA

Aurora TX enables secondary structure characterization of a wide range of biomolecules including RNA, LNPs, proteins, peptides, antibodies, ADCs, and AAVs by measuring change in stability due to buffer, pH, formulation, stress, point mutations, binding, and storage time/conditions.

Infos / Datasheet

By incorporating Aurora TX into your suite of analytical tools, you will add the value of monitoring stability, structure, similarity, concentration and intermolecular aggregation – all measured from a single automated run, with only one drop of sample and analysed with a simple, state-of-the-art spectral analysis engine.

Save time and money by collecting structural data under experimentally/therapeutically relevant conditions; no need to buffer exchange or dilute prior to measuring.

Aurora TX makes analyzing RNA structure easy, utilizing Microfluidic Modulation Spectroscopy (MMS) a nearly drift-free, background-compensated scan of the Amide I band (1700-1600 cm-1), typically used on proteins, but also ideal for nucleic acid characterization.

Thermal ramping applies stress in a repeatable and automated fashion to induce structural change and guide decision-making and candidate ranking, saving valuable R&D time.

The BENEFITS of measuring HIGHER ORDER STRUCTURE

  • Track and maintain the critical relationship between structure and function
  • Identify conditions and processes that introduce undesired structural changes or aggregation
  • Test mechanistic hypotheses behind changes in activity and stability with structural information
  • Publish sooner and finish projects on-time with high repeatability and sensitivity minimizing inconclusive results and reliance upon orthogonal techniques

Key Features and Benefits of Aurora TX

  • Minimum quantities of precious samples are no longer a limitation
  • 50 µL of sample is all you need for highly reproducible structural data
  • broad dynamic range from 0.1 to 100 mg/ml
  • Real-time buffer/background subtraction enables structural analysis under relevant conditions without the need for buffer exchange
  • optional buffer station enhances throughput
  • integrated Thermal Ramping
  • high quality, reproducible results without the limitations of historical secondary structure tools like Circular Dichroism – CD or Fourier-Transform Infrared Spectroscopy – FTIR.
  • Benchtop-friendly, space-saving design
  • Walkaway automation with the convenience of a standard 96-well plate
  • Automation from sample analysis to data processing safes time and reduces user error
  • No spectroscopy expertise required to interpret results- delta software analyzes the data and provides meaningful conclusions