{"id":4153,"date":"2020-04-24T10:03:39","date_gmt":"2020-04-24T08:03:39","guid":{"rendered":"https:\/\/www.prager-elektronik.at\/?post_type=product&#038;p=4153"},"modified":"2024-09-11T14:38:40","modified_gmt":"2024-09-11T12:38:40","slug":"alto","status":"publish","type":"product","link":"https:\/\/www.prager-elektronik.at\/en\/produkte\/life-science\/localized-surface-plasmon-resonance-lspr\/alto\/","title":{"rendered":"Alto SPR System"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/2&#8243;]<div class=\"title-wrapper  basel-title-color-default basel-title-style-default basel-title-size-small text-left \"><div class=\"liner-continer\"> <span class=\"left-line\"><\/span> <h4 class=\"title\" >Nicoya Alto<span class=\"title-separator\"><span><\/span><\/span><\/h4> <span class=\"right-line\"><\/span> <\/div><\/div>[vc_column_text]<strong>Surface Plasmon Resonance powered by Digital Microfluidics.<\/strong><\/p>\n<p>Alto is the world\u2019s first digital high-throughput benchtop SPR system to integrate digital microfluidics (DMF), artificial intelligence (AI), and nanotechnology to provide high quality, label-free determination of the equilibrium dissociation constant K<sub>d<\/sub> and the association and dissociation rates K<sub>on<\/sub> \/ K<sub>off<\/sub> of biochemical interactions with high sample throughput.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;]<div class=\"title-wrapper  basel-title-color-default basel-title-style-default basel-title-size-small text-left \"><div class=\"liner-continer\"> <span class=\"left-line\"><\/span> <h4 class=\"title\" >Infos \/ Datasheet<span class=\"title-separator\"><span><\/span><\/span><\/h4> <span class=\"right-line\"><\/span> <\/div><\/div>[vc_column_text]<\/p>\n<ul>\n<li class=\"pdf\"><a href=\"https:\/\/www.prager-elektronik.at\/wp-content\/uploads\/2020\/04\/katalog_kategorie_life-science_alto-brochure.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Alto Brochure<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]DMF technology enables all fluidics to be disposable, allowing for precise handling of 2\u00b5L sample volumes, crude sample compatibility and zero maintenance.<br \/>\nAlto\u2019s compatibility with automation for both hardware and software provides sample-in\/answer-out data, industry leading throughput and 24\/7 runtime.<\/p>\n<p><strong>Digital Microfluidics<\/strong><\/p>\n<p>DMF is a liquid-handling technology capable of accurately controlling and manipulating discrete nanodroplets with electricity on a standard microwell plate.<br \/>\nDMF fluidic handling technology removes the need for any physical pumps, valves, or tubes and replaces them with a low-cost disposable cartridge, providing higher data quality and less hands-on time.<br \/>\nWe have integrated our proprietary localized surface plasmon resonance (LSPR) sensors into DMF cartridges \u2013 creating 16 independently addressable channels on a single cartridge.<\/p>\n<p><strong>Advantages of using DMF-powered SPR<\/strong><\/p>\n<ul>\n<li>Full kinetics for bio molecular interactions from only 2\u03bcl sample volume<\/li>\n<li>Automated serial dilutions\u2014reducing human error and saving time<\/li>\n<li>Decoupling of interaction time from sample volume, increasing assay flexibility<\/li>\n<li>Decoupling of flow rate and sensor position from dispersion, increasing data quality<\/li>\n<li>No fluidic pathways in the instrumentation \u2013 no pumps, valves or tubes<\/li>\n<li>No clogging, leaking, or contamination.<\/li>\n<\/ul>\n<p><strong>Alto Cartridges<\/strong><\/p>\n<p>Alto Cartridges have completely revolutionized the interaction of fluidics and sensors for SPR.<br \/>\nA Cartridge is a well-plate sized consumable that integrates reagent\/sample storage, fluid handling and sensor surfaces. Samples, buffers and reagents are contained in wells on the cartridge, and dispensed towards the sensor in software-controlled nanodroplets.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Precise volumes and automated serially diluted concentrations interface with a fiber optic sensor tip, manufactured with the same quality and consistency (&lt;2% CV) as our existing localized SPR sensors.<\/p>\n<p>Currently we offer our Cartridges with<br \/>\n<strong>Carboxyl<\/strong> sensor surface<br \/>\n<strong>Anti-HIS <\/strong>(kit)<br \/>\n<strong>Protein A <\/strong>(kit)<br \/>\n<strong>Streptavidin <\/strong>(kit)[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;4236&#8243; img_size=&#8221;large&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<strong>Applications<\/strong><\/p>\n<ul>\n<li>Binding Kinetics\/Affinity<\/li>\n<li>Kinetics\/Affinity Screening<\/li>\n<li>Quantitation<\/li>\n<li>Epitope Mapping\/Binning<\/li>\n<\/ul>\n<p><strong>Compatible With<\/strong><\/p>\n<ul>\n<li>Proteins \/ Peptides<\/li>\n<li>Antibodies<\/li>\n<li>Nucleic Acids<\/li>\n<li>Carbohydrates<\/li>\n<li>Crude samples<\/li>\n<li>Viruses<\/li>\n<li>Small Molecules (application dependent)<\/li>\n<\/ul>\n<p><strong>Publications<\/strong><\/p>\n<p><a href=\"https:\/\/nicoyalife.com\/publications\/\" target=\"_blank\" rel=\"noopener\">Publications<\/a> are provided on Nicoya&#8217;s webpage.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<template id=\"brlbs-cmpnt-cb-template-google-maps-event-on\">\n <div class=\"brlbs-cmpnt-container brlbs-cmpnt-content-blocker\" data-borlabs-cookie-content-blocker-id=\"google-maps-event-on\" data-borlabs-cookie-content=\"\" ><div class=\"brlbs-cmpnt-cb-preset-b brlbs-cmpnt-cb-google-maps-event-on\"> <div class=\"brlbs-cmpnt-cb-thumbnail\" style=\"background-image: url('https:\/\/www.prager-elektronik.at\/wp-content\/uploads\/borlabs-cookie\/1\/brlbs-cb-google-maps-main.png')\"><\/div> <div class=\"brlbs-cmpnt-cb-main\"> <div class=\"brlbs-cmpnt-cb-content\"> <p class=\"brlbs-cmpnt-cb-description\">Sie sehen gerade einen Platzhalterinhalt von <strong>Google Maps<\/strong>. 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Um auf den eigentlichen Inhalt zuzugreifen, klicken Sie auf die Schaltfl\u00e4che unten. Bitte beachten Sie, dass dabei Daten an Drittanbieter weitergegeben werden.<\/p> <a class=\"brlbs-cmpnt-cb-provider-toggle\" href=\"#\" data-borlabs-cookie-show-provider-information role=\"button\">Mehr Informationen<\/a> <\/div> <div class=\"brlbs-cmpnt-cb-buttons\"> <a class=\"brlbs-cmpnt-cb-btn\" href=\"#\" data-borlabs-cookie-unblock role=\"button\">Inhalt entsperren<\/a> <a class=\"brlbs-cmpnt-cb-btn\" href=\"#\" data-borlabs-cookie-accept-service role=\"button\" style=\"display: inherit\">Erforderlichen Service akzeptieren und Inhalte entsperren<\/a> <\/div> <\/div> <\/div><\/div>\n<\/template>\n<script>\n(function() {\n        const template = document.querySelector(\"#brlbs-cmpnt-cb-template-facebook-content-blocker\");\n        const divsToInsertBlocker = document.querySelectorAll('div.fb-video[data-href*=\"\/\/www.facebook.com\/\"], div.fb-post[data-href*=\"\/\/www.facebook.com\/\"]');\n        for (const div of divsToInsertBlocker) {\n            const blocked = template.content.cloneNode(true).querySelector('.brlbs-cmpnt-container');\n            blocked.dataset.borlabsCookieContent = btoa(div.outerHTML);\n            div.replaceWith(blocked);\n        }\n})()\n<\/script><\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Surface Plasmon Resonance powered by Digital Microfluidics. Alto is the world\u2019s first digital high-throughput benchtop SPR system to integrate<\/p>\n","protected":false},"featured_media":4154,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"product_cat":[281,70],"product_tag":[1456,1457,1521,1522,1458,1459,1460,1461,1241,1462,1463,1464,1465,1468,1520,1469,1466,1467,1470,1471,1472,1473,1474,1475,1476,1477,1478,1479,1480,1481,1482,1483,1484,1485,1486,1523,1487,1488,1489,1524,1490,1491,1492,1493,1494,1495,1496,1497,1498,1499,1500,1501,1525,1526,1502,1527,1528,1529,1503,1504,1505,1506,1507,1240,1239,1209,1508,1509,1530,1531,1510,1511,1512,1513,1514,1515,1532,1516,1517,1518,1519],"class_list":{"0":"post-4153","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-localized-surface-plasmon-resonance-lspr","7":"product_cat-life-science","8":"product_tag-affinitaet","9":"product_tag-affinitaet-screening","10":"product_tag-affinitaetscharakterisierung","11":"product_tag-affinitaetsdaten","12":"product_tag-affinity","13":"product_tag-affinity-screening","14":"product_tag-alto","15":"product_tag-alto-spr","16":"product_tag-antikoerper","17":"product_tag-association-rate","18":"product_tag-assoziationsrate","19":"product_tag-automated-serial-dilutions","20":"product_tag-benchtop-spr","21":"product_tag-binding-affinity","22":"product_tag-binding-kinetics","23":"product_tag-binding-kintetic","24":"product_tag-bindungsaffinitaet","25":"product_tag-bindungskinetik","26":"product_tag-bio-molecular-interactions","27":"product_tag-biochemical-interactions","28":"product_tag-biochemische-interaktion","29":"product_tag-biochemische-reaktion","30":"product_tag-biochemische-wechselwirkung","31":"product_tag-crude-samples","32":"product_tag-digital-microfluidics","33":"product_tag-digitale-mikrofluidik","34":"product_tag-dissociation-constant","35":"product_tag-dissociation-rate","36":"product_tag-dissoziationskonstante","37":"product_tag-dissoziationsraten","38":"product_tag-dmf","39":"product_tag-epitop-binning","40":"product_tag-epitop-mapping","41":"product_tag-epitope-binning","42":"product_tag-epitope-mapping","43":"product_tag-epitopkartierung","44":"product_tag-equilibrium-dissociation-constant","45":"product_tag-gleichgewichtsdissoziationskonstante","46":"product_tag-interaktion-von-biomolekuelen","47":"product_tag-interaktionsanalyse","48":"product_tag-kd","49":"product_tag-kd-kon-koff","50":"product_tag-kinetics","51":"product_tag-kinetics-for-bio-molecular-interactions","52":"product_tag-kinetics-screening","53":"product_tag-kinetik","54":"product_tag-kinetik-screening","55":"product_tag-kinetikdaten","56":"product_tag-koff","57":"product_tag-kohlenhydrate","58":"product_tag-kon","59":"product_tag-label-free","60":"product_tag-lokalisierte-oberflaechenplasmonenresonanz","61":"product_tag-lspr","62":"product_tag-markierungsfrei","63":"product_tag-molekulare-bindungskinetik","64":"product_tag-molekulare-wechselwirkungen","65":"product_tag-molekularer-interaktionen","66":"product_tag-nukleinsaeuren","67":"product_tag-oberflaechenplasmonenresonanz","68":"product_tag-oberflaechenplasmonenresonanzspektroskopie","69":"product_tag-oberflaechenplasmonenresonanzspektroskopiesystem","70":"product_tag-on-off-rate","71":"product_tag-peptide","72":"product_tag-proteine","73":"product_tag-proteins","74":"product_tag-quantifizierung","75":"product_tag-quantitation","76":"product_tag-screening","77":"product_tag-sensoroberflaeche","78":"product_tag-serielle-verduennung","79":"product_tag-small-molecules","80":"product_tag-spr","81":"product_tag-spr-leck","82":"product_tag-spr-sensor","83":"product_tag-spr-sensoroberflaeche","84":"product_tag-spr-system","85":"product_tag-spr-verstopft","86":"product_tag-surface-plasmon-resonance","87":"product_tag-unaufgereinigte-proteine","88":"product_tag-viren","90":"first","91":"instock","92":"shipping-taxable","93":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9 - 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